Extended Data Fig. 2: Comparison between synaptic plasticity models using the frequency-dependent STDP protocol. | Nature Neuroscience

Extended Data Fig. 2: Comparison between synaptic plasticity models using the frequency-dependent STDP protocol.

From: Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks

Extended Data Fig. 2

a-c, Relevant variables at the moment of synaptic plasticity induction as a function of the frequency of spike pairs with pre-before-post (top; Δt = + 10 ms) and post-before-pre (bottom; Δt = − 10 ms). Synaptic plasticity is induced at the moment of either a postsynaptic spike, tpost (or \({t}_{{{{\rm{post}}}}}^{{{{\rm{AP}}}}}\)), or a presynaptic spike, \({t}_{{{{\rm{pre}}}}}\). a, Average of the traces of NMDA currents (left; E(tpost)), presynaptic spikes (right; \({x}_{{{{\rm{pre}}}}}^{+}\) (tpost)), and postsynaptic spikes (right; \({y}_{{{{\rm{post}}}}}^{{{{\rm{E}}}}}\) (tpost) and \({t}_{{{{\rm{post}}}}}^{-}\) (\({t}_{{{{\rm{pre}}}}}\))). b, Same as panel a, right, for the spike-based triplet STDP model. c, Average of the traces of presynaptic spikes (left; \({t}_{{{{\rm{pre}}}}}\) (\({t}_{{{{\rm{post}}}}}^{{{{\rm{AP}}}}}\))) and postsynaptic membrane potential (right; u(\({t}_{{{{\rm{post}}}}}^{{{{\rm{AP}}}}}\)), u+ (\({t}_{{{{\rm{post}}}}}^{{{{\rm{AP}}}}}\)), and u+ (\({t}_{{{{\rm{pre}}}}}\))). Dashed and continuous lines show averages for zero (weff = 0) and non-zero (weff = w) synaptic weights. d-g, Plasticity inducing protocol for different models with pairs of pre-before-post (Δt = + 10 ms) and post-before-pre (Δt = − 10 ms) for varying spiking frequencies, and different firing-rates of neighbouring excitatory and inhibitory afferents (colour coded). Plots show changes in synaptic weight of a single connection while the other two (excitatory and inhibitory) are kept fixed. Spike-based triplet spike-timing-dependent plasticity model from ref. 5 and voltage-based plasticity model from ref. 6. h-k, Weight change as a function of neighbouring synapses’ input frequency (y-axis), and frequency of spike pairs (x-axis). Arrows indicate external frequencies used in panels d-g. Plots from panels d and h are also shown in Fig. 2e,f. Error bars indicate SEM. Experimental data in panels d-g was adapted with permission from ref. 15 (we refer to ref. 15 for information about sample sizes and statistical analysis).

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