Extended Data Fig. 3: Effect of VTA dopaminergic neuron inhibition on reward-evoked striatal firing rates.
From: Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling
a. Mean firing rate changes for neurons of each cell type (eNpHR3 animals: n = 435 MSN, 73 FSI, 58 TAN; control animals: n = 339 MSN, 63 FSI, 37 TAN; one-way ANOVA, cell type x group effect: F5,999 = 6.937, P < 0.0001). Post-hoc Sidak’s test comparing eNpHR3 animals and controls: MSN (P = 0.25), FSI (P < 0.0001), TAN (P = 0.99). Data represent mean ± SEM. b. Mean firing rate changes for neurons of each cell type group by ML position. One-way ANOVA: MSN ML position effect (F3,431 = 3.193, P = 0.02), FSI ML position effect (F3,69 = 0.869, P = 0.46), TAN ML position effect (F3,54 = 0.474, P = 0.70). Post-hoc Tukey’s test for MSN: P = 0.0529 for 1.05 mm vs. 1.45 mm. Data in this figure represent mean ± SEM. c. Mean firing rate changes for neurons of each cell type group by DV position. One-way ANOVA: MSN DV position effect (F3,431 = 4.557, P = 0.004), FSI DV position effect (F3,69 = 0.904, P = 0.44), TAN DV position effect (F3,54 = 1.002, P = 0.40). Post-hoc Tukey’s test for MSN: P = 0.005 for 4.4 mm vs. 5.0 mm, P = 0.02 for 4.7 mm vs. 5.0 mm. Data represent mean ± SEM. d. Comparison of TAN pause duration in eNpHR3 expressing animals across R and R + L trial types (n = 29 TANs, paired two-sided t-test, t = 0.3825, P = 0.7). Data represent mean ± SEM.
