Fig. 6: ME contains capillary-associated fibroblasts. | Nature Neuroscience

Fig. 6: ME contains capillary-associated fibroblasts.

From: Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells

Fig. 6

a, TEM images of Pdgfra-CreER HRP reporter after DAB reaction in the ME. HRP is detected in the endoplasmic reticulum (white arrowheads) of Pdgfra-expressing fibroblast cells. b, Fluorescent labeling of fibroblasts in the cortex and ME using Pdgfra-CreER:Ai14 mice after low-dose 4OH-tamoxifen to achieve sparse cell labeling. Left: Tomato+ fibroblasts (red). Right column: merged with immunostaining for CD31 (white). Yellow arrow indicates artery. c, Co-immunostaining for fibroblasts with DECORIN (white) and collagen 1 (green) in cortex and ME.

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