Extended Data Fig. 1: Between-subjects spectral power analysis.
Box plots show the median, quartiles, minima and maxima, while violin plots show the density distribution of the mean whole-brain relative spectral power values for the delta, theta, alpha and beta frequency bands across subjects with no AD pathology (Aβ−/Tau−, n = 50), subjects with widespread Aβ expression and low entorhinal tau (Aβ+/Tau−, n = 42) and subjects with both Aβ and entorhinal tau burden (Aβ+/Tau+, n = 11). Mean relative power brain maps for each subgroup are shown on top of each plot. Two-sided, one-factor ANCOVAs were performed to assess the main effect of group on whole-brain relative power. A neurophysiological slowing effect was observed for the Aβ+/Tau+ compared to the Aβ+/Tau− group, reflected as an increase in whole-brain delta (F(2, 95) = 4.58, pFDR = 0.025) and theta (F(2, 95) = 4.76, pFDR = 0.025) power and a decrease in alpha (F(2, 95) = 3.15, pFDR = 0.047) and beta (F(2, 95) = 3.79, pFDR = 0.034) power. Brackets indicate the results from post hoc comparisons to assess significant differences between the groups, with their corresponding Tukey HSD p-values adjusted for multiple comparisons. ns: non-significant.
