Table 2 Whole-brain averaged between-participants spectral power analysis

From: Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults

Between-participants spectral power analysis

MEG frequency band

Aβ−/Tau− mean (CI)

Aβ+/Tau− mean (CI)

Aβ+/Tau+ mean (CI)

ANCOVA F statistic

P value

Aβ−/Tau− versus Aβ+/Tau−

Aβ−/Tau− versus Aβ+/Tau+

Aβ+/Tau− versus Aβ+/Tau+

Delta-band (2–4 Hz)

0.32 (0.30–0.35)

0.29 (0.27–0.31)

0.37 (0.30–0.44)

4.58 (2,95)

0.025

0.119

0.244

0.016

Theta-band (5–7 Hz)

0.21 (0.20–0.22)

0.19 (0.19–0.20)

0.23 (0.20–0.27)

4.76 (2,95)

0.025

0.120

0.213

0.013

Alpha-band (8–12 Hz)

0.25 (0.23–0.28)

0.28 (0.26–0.31)

0.21 (0.16–0.27)

3.15 (2,95)

0.047

0.236

0.336

0.054

Beta-band (15–29 Hz)

0.11 (0.10–0.13)

0.13 (0.12–0.14)

0.09 (0.07–0.12)

3.79 (2,95)

0.034

0.240

0.224

0.025

  1. Summary of the between-participants analysis comparing whole-brain neurophysiological activity spectral power across PET-defined groups. Values indicate the mean and confidence intervals of the relative power for each frequency band, followed by statistics from the two-sided, one-factor ANCOVA test (F statistic (df) and FDR corrected P values) and post hoc pairwise comparisons (Tukey’s Honestly Significant Difference [HSD] test adjusted P values). Significant differences between the groups (corrected P < 0.05) are highlighted in bold. Aβ+/Tau+ individuals showed increased low-frequency power (delta and theta bands) and decreased fast-frequency activity (beta band and trend in alpha band), when compared to the Aβ+/Tau− individuals.
  2. CI, confidence interval.