Extended Data Fig. 9: Extended comparisons between CTRL and MS samples.
From: Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
a, b, c, Volcano plot of DEGs from OL, AS and MC for the contrast CTRL vs MS-CA, CTRL vs MS-CI and MS-CA vs MS-CI, respectively. Color indicates association to a condition. d, Dot plot of enriched pathways for DEGs of OL, AS and MC, grouped by condition. e, f, Remaining cell type and subtype compositional changes across conditions, respectively (n = 6 for CTRL, n = 6 for MS-CA, n = 4 for MS-CI) (two-tailed Wilcoxon rank-sum test, BH adjusted P < 0.10). g, Volcano plot of DEGs for PPWM and LC niches, respectively. Color indicates association to an MS lesion type. Violin plots illustrate the median (represented by the white dot), the 25th percentile (Q1), and the 75th percentile (Q3), with the ends of the black box indicating Q1 and Q3; the whiskers extend to the furthest datapoint within 1.5 times the interquartile range (IQR), specifically 1.5 * (Q3 - Q1), beyond Q3 or below Q1.
