Fig. 4: The vLGN suppresses behaviorally induced sensory blur.
a, Spontaneous saccades on a stationary grating or checkerboard (‘saccades’, top, black) and saccade-like shifts of the displayed texture during stationary eye periods (‘pseudosaccades’, bottom, green) induce comparable image shifts. b, Density-colored scatter plot of normalized responses of individual retinal boutons comparing pseudosaccades and saccades, showing stronger responses to pseudosaccades (linear fit: gray line, slope = 0.89, P = 5.5 × 10−14, paired, two-tailed Wilcoxon signed rank test, n = 5,174). c, Same as b but for vLGN boutons with a strong preference for saccadic motion (linear fit: gray line, slope = 0.42, P < 10 × 10−130, paired, two-tailed Wilcoxon signed rank test, n = 51,996). d, Histograms of the bouton-wise pseudosaccade preference index for RGC (gray) and vLGN (yellow) bouton responses as in b and c, with vLGN bouton preference shifted to the negative compared with RGC (P < 10 × 10−130, two-tailed Wilcoxon rank sum test, vLGN: mean −0.310 ± 0.214 s.d., RGC: mean −0.030 ± 0.187 s.d.). e, Schematic of virally mediated TeLC expression in vLGN and SC extracellular recording. f, Confocal micrograph of TeLC-tdTomato expression (orange) in thalamus of Gad2-cre mice. Scale bar, 100 µm; n = 4 animals. g, Normalized peristimulus time histogram (PSTH) of mean saccade-triggered responses in control (left) and TeLC (right) mice (control n = 370 units, 8 recordings, 5 animals; TeLC n = 295 units, 6 recordings, 4 animals). h, Normalized population-averaged saccade responses and s.e.m. (shading). i, Average firing rate for the first 200 ms after saccade onset for all units in g (P = 10 × 10−18, KS (Kolmogorov-Smirnov) test).
