Extended Data Fig. 4: nAChRs limit summation of intracellular calcium in DA axons during a train of electrical stimulation ex vivo.
From: An axonal brake on striatal dopamine output by cholinergic interneurons
a, Examples of GCaMP6f fluorescence signals, ΔF/F (mean ± SEM from duplicates) in a DA axon population imaged in DLS ex vivo in response to single or trains of 4 electrical pulses (4p) at 143 Hz (7 ms inter-stimulation interval) in control conditions (left) and in the presence of DHβE (1 μM) (right). b, Mean peak values (± SEM) for GCaMP6f ΔF/F vs. pulse numbers. Data are normalised to value for 1 pulse (n = 5 recordings, N = 2 animals). **P = 0.0025 two-sided paired t-test [DA]o from 4 pulses of stimulation.
