Fig. 4: Peripheral organ pathology in brain- and body-first groups.

a, Frequency of cases showing Lewy pathology in at least one peripheral tissue in brain-first (red) and body-first (blue) groups. Sample sizes of brain- and body-first groups for each dissemination category are listed in Table 1. b, Summed Lewy pathology severity scores across the four peripheral organs (HE, ESO, ADR and skin) in brain- and body-first groups. Sample sizes of brain- and body-first groups for each dissemination category are listed in Table 1. Data are plotted as average and s.e.m. c, A comparison of the absolute number of cases with confirmed pathology in a single region, within the BBAR and Newcastle datasets. In the Newcastle dataset, no information on OB or AMY was consistently available.