Extended Data Fig. 1: Lewy pathology in substantia nigra of brain- and body-first subgroups. | Nature Neuroscience

Extended Data Fig. 1: Lewy pathology in substantia nigra of brain- and body-first subgroups.

From: Sympathetic and parasympathetic subtypes of body-first Lewy body disease observed in postmortem tissue from prediagnostic individuals

Extended Data Fig. 1: Lewy pathology in substantia nigra of brain- and body-first subgroups.

Left. The cumulative area under the curve (AUC) of LBD severity scores is larger in the SN of brain-first (red) than in body-first (blue) LBD in comparable intervals of regions. Right. The AUC values in the table suggest that brain-first cases may be diagnosed with PD based on motor symptoms at earlier dissemination stages compared to body-first, since brain-first cases accumulate more Lewy pathology in the SN at earlier dissemination stages.

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