Table 1 Clinical, demographic and neuropathological data of cases stratified into eight dissemination categories
Regions positive | 1–2 | 3–4 | 5–6 | 7–8 | 9–10 | 11–12 | 13–14 | 15–16 |
|---|---|---|---|---|---|---|---|---|
Age (avg) (years) | 83 | 81 | 84 | 82 | 87 | 81 | 86 | 85 |
Cases (n) | ||||||||
Total | 32 | 20 | 4 | 18 | 9 | 21 | 34 | 35 |
Brain-first | 17 | 14 | 2 | 7 | 4 | 10 | 9 | 6 |
Body-first | 13 | 6 | 2 | 6 | 4 | 5 | 10 | 8 |
Indeterminate | 2 | 0 | 0 | 5 | 1 | 6 | 15 | 21 |
PD or DLB (n) | ||||||||
Total | 0 | 0 | 0 | 0 | 0 | 3 | 16 | 25 |
Brain-first | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 3 |
Body-first | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 5 |
Indeterminate | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 17 |
AD (n) | ||||||||
Total | 7 | 4 | 1 | 2 | 1 | 5 | 10 | 6 |
Brain-first | 7 | 4 | 1 | 2 | 1 | 4 | 4 | 2 |
Body-first | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Indeterminate | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 4 |
Braak α-syn (avg) | 0.81 | 2.00 | 2.75 | 3.00 | 3.22 | 3.57 | 4.79 | 5.17 |
Braak α-syn (PD or DLB) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.00 | 5.13 | 5.60 |
BBAR α-syn (avg) | 0.72 | 0.83 | 1.00 | 0.97 | 1.22 | 1.57 | 3.23 | 3.48 |
NFT (avg) | 2.78 | 2.75 | 3.25 | 2.56 | 2.78 | 2.67 | 3.06 | 2.51 |
SP (avg) | 1.63 | 1.50 | 2.00 | 1.28 | 1.44 | 1.48 | 1.94 | 1.57 |
Clinical stage | Prediagnostic | Prediagnostic | Prediagnostic | Prediagnostic | Prediagnostic | Mostly prediagnostic | Postdiagnostic | Postdiagnostic |
