Extended Data Fig. 8: MBNL and SRRM proteins directly bind to Ank2 and regulate miE splicing. | Nature Neuroscience

Extended Data Fig. 8: MBNL and SRRM proteins directly bind to Ank2 and regulate miE splicing.

From: Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes

Extended Data Fig. 8

a, Schematic of heterologous Atp2a1-Ank2 miE splicing minigenes production. MBNL (magenta) and SRRM (purple) binding sequences identified in mouse Ank2. b,c, Atp2a1-Ank2 miE splicing analysis in N2a experiments (N = 3). One-way ANOVA followed by Tukey’s multiple comparisons test; nsPadj > 0.05, **Padj < 0.01, ***Padj < 0.001, ****Padj < 0.0001. Data are presented as mean values ± SD.

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