Extended Data Fig. 9: Lack of a locomotor deficit in Mbnl2 KO mice. | Nature Neuroscience

Extended Data Fig. 9: Lack of a locomotor deficit in Mbnl2 KO mice.

From: Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes

Extended Data Fig. 9

a, 13 parameters were measured during the 25-minute (5–30 min) interval of the open field test. WT mice (N = 11), Mbnl2 KO (N = 12). Two-tailed t-test or two-tailed Mann-Whitney (U) test. b, Percentage of nestlet shredding. WT mice (N = 13), Dmpk-(CTG)480/480 (N = 10). Two-tailed Mann-Whitney test; **P = 0.0039. c, Number of buried marbles. WT mice (N = 17), Mbnl2 KO (N = 14). Two-tailed t-test: P = 0.1455 (t = 1.496, df=29). a,b,c, Box plot shows the lower, middle, and upper quartiles. Whiskers show minimum and maximum.

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