Extended Data Fig. 5: Bottom–up signaling cannot explain the enhanced interhemispheric synchrony in expert mice.
From: Bilateral integration in somatosensory cortex is controlled by behavioral relevance
a, Interhemispheric touch rate as a function of touch lags for expert (n = 10 mice) and naive mice (7 mice). b, Box plot of IH touch rates for hit and correct reject trials in expert mice (p = 5.2e−4, 2-sample t test, n = 10 mice) and naive mice (p = 0.76, 2-sample t test, n = 7 mice). c, Population-averaged interhemispheric firing rates as a function of temporal lag between pairs of neurons during the baseline period in an expert mouse. Pairs of neurons with their individual firing rates during prestimulus period (Blf) greater than 4, 6, 8 and 10 Hz. d, Prestimulus IH spike rates of stimulus-responsive neurons with comparison of their baseline firing rates (Blf) >4 Hz (n = 8 mice and m = 367 cells), >6 Hz (n = 8 mice and m = 292 cells), >8 Hz (n = 8 mice and m = 238 cells) and >10 Hz (n = 8 mice and m = 194) in expert mice. e, Prestimulus IH spike rates comparing expert mice (n = 8 mice and m = 367 cells) and naive mice (n = 4 mice and m = 201 cells). Cells with Blf >4 were used for IH spike rate calculation. f, Relationship between IH touch interval (ITI) and spike coincidence (jPSTH) in expert and naive mice. g, Schematic illustrating the generation of predicted spike coincidence from the unilateral touch-triggered PSTHs. The real bilateral ITIs were used to match the temporal relationship of the unilateral touches to the actual bilateral stimulus. h, Average spike coincidence across the conditions (real vs. predicted) in expert (n = 8 mice, m = 783 cells) and naive mice (n = 4 mice, m = 409 cells). All box plots are defined with median (center), 25th percentile, 75th percentile as bounds, whiskers extending up to 1.5× interquartile range and outliers beyond this range. All error bars represent the mean ± s.e.m. All statistical tests are two-sided.
