Extended Data Fig. 8: EOPN3-mediated ipsilateral response suppression and unchanged whisker kinematics.
From: Bilateral integration in somatosensory cortex is controlled by behavioral relevance
a, Histogram of firing rate of an example neuron aligned to the onset of ipsilateral touch during the control and light conditions. b, Scatter plot comparing ipsilateral firing rates between the control and light conditions for all neurons with a significant ipsilateral touch-evoked response (eOPN3—26 neurons in 5 mice, p = 0.01; tdTomato—15 neurons in 3 mice, p = 0.81, Wilcoxon signed-rank test). c, Rasters and histograms of trial-averaged firing rates in two example neurons aligned to the onset of ipsilateral touch during control (black) and light (magenta) trials in mice expressing eOPN3. d, Ipsilateral touch rate aligned to the onset of ipsilateral touch during control and light trials in a mouse expressing eOPN3. e, Scatter plot of the mean normalized (divided by baseline rate) firing rate of neurons during control and light trials in mice expressing eOPN3 (41 neurons in 5 mice, p = 3.7e−8, signed-rank test). f, Left, whisker curvature aligned to the onset of touch during the control and light conditions. Right, scatter plot of mean whisker curvature calculated during the control and light conditions. All error bars represent the s.e.m. All statistical tests were two-sided.
