Extended Data Fig. 1: Behavior and longitudinally registered neurons in implanted mice.
From: Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles
a, Center and bottom of implant tracts of all included mice from anterior (left) to posterior (right) granular RSC. b, Individual freezing from data in Fig. 2f with all multiple comparisons shown. From top to bottom: Habituation, Acquisition, Extinction 1, Extinction 2, Extinction 3 (Acquisition: F(trial period)(6,126) = 137.9, P < 0.0001; Extinction 1: F(trial period)(6, 126) = 7.239, P < 0.0001, Extinction 3: F(interaction)(18,126) = 2.582, P = 0.0011, F(trial period)(6,126) = 4.345, P = 0.0005, F(group)(3,21) = 20.53, P < 0.0001; two-way RM ANOVA with Sidak correction; Supplementary Table 1 (rows 6–10)). c, Normalized cross-correlation (NCC) scores of longitudinally registered ROIs with respect to Habituation. Left: heatmap of NCC scores for each ROI across days. Right: histogram of average NCC scores. d, Centroid distances of longitudinally registered ROIs with respect to Habituation. Left, heatmap of centroid distances for each cell across days. Right: histogram of average centroid distances. e,f, Fraction of tone- (e) and trace-responsive (f) cells that are responsive for 1–5 days in each animal. g, Average freezing encoding (auROC) in longitudinally registered neurons across days (F(session)(4,84) = 9.337, P < 0.0001; two-way RM ANOVA with Sidak correction; Supplementary Table 1 (row 17). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ****P ≤ 0.0001.
