Extended Data Fig. 2: In the embryonic mouse brain, Htr2c is selectively expressed in ChP.
From: Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development
(A) Bar graph of E14.5 and P0 Htr2c expression reveals that, throughout the mouse neocortex, ChP expresses Htr2c during embryonic development. Notably, Htr2c is not expressed in progenitors. Created with the Zylka Lab’s Single-cell transcriptomic analysis of mouse neocortical development gene-by-gene search webpage with data from Loo et al.1. https://zylkalab.org/datamousecortex (B) Violin plot of E14 Htr2c expression demonstrates high ChP Htr2c expression in mouse brain at E14.5. created with Broad Institute Single Cell Portal from Mouse E14 brain single nucleus RNA sequencing data gathered for Russell et al.2. https://singlecell.broadinstitute.org/single_cell/study/SCP2170/slide-tags-snrna-seq-on-mouse-embryonic-e14-brain (C) Expression of Htr2c in E13.5, E15.5, E18.5, and P4 mouse brain shows that before E18.5, Htr2c is highly and predominantly expressed in ChP. At E18.5, low expression arises in brainstem nuclei. At P4, Htr2c expression is widespread. Allen Developing Mouse Brain Atlas, developingmouse.brain-map.org/experiment/show/100047619.
