Extended Data Fig. 4: TBG exhibits limited efficacy at several targets implicated in the effects of antidepressants. | Nature Neuroscience

Extended Data Fig. 4: TBG exhibits limited efficacy at several targets implicated in the effects of antidepressants.

From: The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

Extended Data Fig. 4: TBG exhibits limited efficacy at several targets implicated in the effects of antidepressants.

(a) Functional assays of TrkB activation demonstrate that the positive control (BDNF) is a full agonist, while TBG has no effect in either agonist or positive allosteric modulator (PAM) mode. (b) TBG is a weaker inhibitor of MAO-A than clorgyline by 3 orders of magnitude. (c) TBG binds to the NET with an affinity that is 4 orders of magnitude lower than desipramine. (d) TBG binds to the SERT with an affinity that is 2 orders of magnitude lower than fluoxetine. Data represent mean ± s.e.m. from two or more replicates. For additional details on statistics, see Table S4.

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