Extended Data Fig. 9: Various snRNA-seq metrics show high quality data with strong consistency across pools and samples from the PFC of mice. | Nature Neuroscience

Extended Data Fig. 9: Various snRNA-seq metrics show high quality data with strong consistency across pools and samples from the PFC of mice.

From: The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

Extended Data Fig. 9: Various snRNA-seq metrics show high quality data with strong consistency across pools and samples from the PFC of mice.The alternative text for this image may have been generated using AI.

(a) UMAP with cells colored by pool and treatment shows consistent spatial distribution in transcriptomic space and within each cluster. (b) Expression of housekeeping gene Actb shows concordance across samples depicted by Seurat’s normalized data of the single cell transform (SCT) assay. (c) Each pool is represented in each cluster with relatively equal proportions in accordance with the total cell number from that sample. There is some variability of the total cell count from each sample but there is no obvious relation to treatment. Cell type labels are positioned in the blue Pool2_TBG area for visibility. (d) Quality control metrics of filtered data are distributed in line with expected ranges and show consistency across batch and sample.

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