Extended Data Fig. 8: Single Nuc seq DEGs indicate that transgene-expressing motor neurons at P21 resemble perinatal motor neurons. | Nature Neuroscience

Extended Data Fig. 8: Single Nuc seq DEGs indicate that transgene-expressing motor neurons at P21 resemble perinatal motor neurons.

From: Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons

Extended Data Fig. 8

a, Heatmap of R2 values for correlations between AAV-Isl1-Lhx3-mediated changes in gene expression vs. maturation-mediated changes in expression between P21 and the indicated time points for alpha and type 3 DEGs. Values for P4 are reported in Fig. 2g. p values for alpha DEGs are as follows: E13.5, p < 0.0001; P4, p < 0.0001; P13, p < 0.0001. p values for type 3 DEGs are as follows: E13.5, p < 0.0001; P4, p < 0.0001; P13, p = 0.0002. Minimum R2 value = 0.03823; maximum R2 value = 0.4063. b, Bubble plot of FDR values for shared, significantly enriched GO terms between up-regulated alpha and type 3 DEGs. Maximum FDR value = 0.0381; minimum FDR value = 8.09E-12. Bubble size represents the percentage of shared DEGs populating each term.

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