Extended Data Fig. 2: Scaling in the theta-modulated bursting frequency is accompanied by changes in other theta-modulated firing properties.
From: Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells
a–b, Change in NPR is predicted by the unit’s initial NPR. a, Histogram of the y-coordinate distance between each unit’s NPR in epoch 3 and the y = x line. A distance of 0 means that the unit scaled its theta-modulated firing frequency perfectly with gain. The units that formed fields in both epochs 1 and 3 were classified as having NPRs close to (distance < median) or further from (distance > median) the theoretical value. b, NPR of the two groups in epoch 1 (n = 33 units). Units that scaled their theta-modulated firing frequencies more faithfully in epoch 3 tended to have higher NPRs in epoch 1. β = 0.461, s.e. = 0.174, t(31) = 2.65, P = 0.0125; t-statistics/two-sided P value from the LMEM. Each violin plot shows the median (white circle), IQR (gray line), and distribution outline. c, Bursting rate was invariant to gain (n = 246 units). Overall: W(3) = 5.25, P = 0.154 (two-sided); Wald test on the LMEM. d, Theta-missing index was invariant to gain (n = 246 units). Overall: W(3) = 2.75, P = 0.432 (two-sided); Wald test on the LMEM. e–g, Quantification of theta-skipping24,58,59,60. e, Autocorrelogram (ACG) of an example unit without theta-skipping. f, Top, ACG of an example unit with theta-skipping. Note the disappearance of peak 1. Bottom, spiking of this unit relative to theta. g, Theta-skipping index was higher (less theta-skipping) in high gain condition compared to mid gain and G = 1 conditions (n = 242 units). Overall: W(3) = 14.6, P = 2.17 ×10−3 (two-sided); Epoch 1 vs. Low: β = −0.0808, s.e. = 0.0500, t(238) = −1.62, P = 0.107, Epoch 1 vs. Mid: β = −0.0438, s.e. = 0.0304, t(238) = −1.44, P = 0.150, Epoch 1 vs. High: β = −0.146, s.e. = 0.0408, t(238) = −3.59, P = 3.98 ×10−4, Low vs. Mid: β = 0.0370, s.e. = 0.0552, t(238) = 0.671, P = 0.503, Low vs. High: β = −0.0656, s.e. = 0.0601, t(238) = −1.09, P = 0.276, Mid vs. High: β = −0.103, s.e. = 0.0458, t(238) = −2.24, P = 0.0259; Wald test followed by t-statistics/two-sided P values from the LMEM. *: P < 0.05, ***: P < 0.001.
