Extended Data Fig. 6: Overlap of hits of in vivo screens with essential genes of iPSC-derived neurons, and DepMap common essential genes. | Nature Neuroscience

Extended Data Fig. 6: Overlap of hits of in vivo screens with essential genes of iPSC-derived neurons, and DepMap common essential genes.

From: CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes

Extended Data Fig. 6

a, Venn diagram showing that 91 of the 147 hit genes for which knockdown decrease neuronal survival in vivo (Fig. 3) overlap with common essential genes of the injected libraries in cancer cell lines described in the DepMap database23, P < 0.0001 by Fisher’s exact test, two-sided. b, Comparison of knockdown phenotype for genes between the in vivo neuronal survival screen of Fig. 3 and survival screens previously performed in iPSC-derived neurons by ref. 2.

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