Fig. 6: Bootstrapping analysis estimates the number of mice required for different in vivo screening conditions. | Nature Neuroscience

Fig. 6: Bootstrapping analysis estimates the number of mice required for different in vivo screening conditions.

From: CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes

Fig. 6

a, Increasing numbers of mice were randomly sampled and bootstrapped from the CaMKII-Cre (left) and hI56i-Cre (right) cohorts to assess how frequently the hits from a bootstrap overlap with the hits identified from their whole respective cohort. Hits are defined by an FDR < 0.1. b, Top, the percentage of individual mice that recover each of the hits defined from analyzing the whole cohort. Bottom, percentage of bootstraps when randomly sampling six mice of the cohort that recover each of the hits of the whole cohort. The left half is the CaMKII-Cre cohort and the right half is the hI56i-Cre cohort.

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