Extended Data Fig. 2: Supplemental cell quantification for treatment paradigms. | Nature Neuroscience

Extended Data Fig. 2: Supplemental cell quantification for treatment paradigms.

From: Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery

Extended Data Fig. 2: Supplemental cell quantification for treatment paradigms.The alternative text for this image may have been generated using AI.

a, Treatment with NBQX or GYKI-53655 did not significantly alter the total number of tdT+ epNSPCs 7dpi. N = 6 mice in vehicle, n = 3 mice in NBQX, n = 3 mice in GYKI-53655. Two way ANOVA. b, Total number of tdT+ epNSPCs was not significantly different between control and cKO groups at 7dpi. N = 4 mice in Foxj1-CreER-tdT, n = 5 mice in Foxj1-CreER-tdT-Gria1-3fl/fl. Two way ANOVA. c, Average distance of epNSPCs from origin in vehicle-treated and CX546-treated groups 6 wks after SCI. N = 15 mice in vehicle, N = 16 mice in CX546. Two way ANOVA. d, Total tdT+ cell counts in vehicle-treated and CX546-treated groups was not significantly different (6 wks after SCI). N = 15 mice in vehicle, N = 16 mice in CX546. Two way ANOVA. e, f, Average distance of epNSPCs from origin and total tdT+ cell counts in CX546-treated and vehicle- treated groups with and without cKO of Gria1-3 genes. N = 15 mice in vehicle, N = 16 mice in CX546, N = 7 mice in cKO+Veh, N = 9 mice in cKO+CX546. Two way ANOVA followed by Tukey’s post hoc multiple comparisons test. Asterisk in e indicates significant difference on pairwise comparisons at 0 mm (P = 0.0384). All data are mean ± s.e.m. *P < 0.05.

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