Extended Data Fig. 2: ELK1 3’-UTR APA reporter library.
From: TDP-43 loss induces cryptic polyadenylation in ALS/FTD
A). ELK1 Cryptic PAS usage in control (‘CTRL’) conditions in a series of reporters with varying changes in UG content (x-axis, %). Original reporter (0); reporters with increasing amounts of UG deletion (20, 24, 32, 48, 56, 60, 96); the reporter where UG content is increased (92). B). Cryptic PAS usage in control and severe TDP-43 knockdown conditions for the original reporter (0), the reporter with increased UG content (92) and the reporter with the most UG deletion (96).
