Extended Data Fig. 4: Motor skill deficits induced by SNI and CFA interventions are reversed by psilocybin.
a,b,d,e, Trajectory for latency to fall (seconds) for individual SNI (a, n = 10, red), sham (b, n = 11, blue), CFA (d, n = 10, gray) and saline (e, n = 10, green) animals over experimental timeline. Thicker line shows the population average. Motor performance declines at day 20, followed by a rapid recovery on day 28 following psilocybin injection. Sham and saline animals show consistent performance across all time points. c,f, Normalized latency to fall on an accelerating rotarod from baseline (day 0). Latency to fall decreases post-injury in (c) SNI (n = 10) and (f) CFA (n = 10) conditions, then increases post-psilocybin injection on day 28 (one-way ANOVA followed by Bonferroni’s multiple comparisons test, SNI: P = 7.9 ×10−5, CFA: P = 1.6 × 10−8). Data are represented as mean. ****P < 0.0001. Detailed statistics are reported in Supplementary Table 1,j.
