Extended Data Fig. 5: Voxel-wise fit.
From: Region-specific drivers of CSF mobility measured with MRI in humans
(A) Percentage of voxels showing coherent CSF mobility changes across phases (that is R2 > 0.5 when fitting a sinusoidal model) relative to the total amount of voxels in the ROI, in eleven individuals. Values are shown for cardiac (left), respiratory (middle) and random binning (right) in six ROIs. Each datapoint represents the value per individual in a region of interest. On each boxplot, the central line indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. The whiskers extend to the most extreme data points not considered outliers, and the outliers are plotted individually using the ‘+‘ marker symbol. (B) Example of the voxel-wise sinusoidal fit (full line, in red) applied to the signal across phases (black dashed line with dots) in three different voxels. The associated fit quality and amplitude are shown above each graph. In the most right panel, the reported amplitude would have be 12%, even though the fit quality to the sinusoid is very low (R2 = 0.22, the corresponding fit is the red dashed line) and does not represent well the CSF mobility change over phases. In that case, an amplitude of 0 is reported instead, as shown by the flat red line to better represent the absence of coupling.
