Fig. 8: CSF-STREAM in patients with CAA versus healthy controls.
From: Region-specific drivers of CSF mobility measured with MRI in humans
a, Example of a 1-mm CSF rim in the SAS around the MCA. b, CSF mobility was significantly increased (P = 0.01, two-sided Mann–Whitney U-test). c, FA was significantly decreased (P = 0.02, two-sided Mann–Whitney U-test) in the 1-mm-thick SAS around the MCA of patients with CAA (pink) versus healthy controls (black). d, ROI volume around the MCA in controls and patients with CAA (P = 0.72, two-sided Mann–Whitney U-test). e, Example of PVS segmentation around penetrating vessels in the CSO. f,g, No significant change in CSF mobility (P = 0.88, two-sided Mann–Whitney U-test) (f) nor FA (P = 0.80, two-sided Mann–Whitney U-test) (g) was found in PVS. h, The PVS volume was significantly increased (P = 0.007, two-sided Mann–Whitney U-test) in patients with CAA. Each data point represents the value per individual (n = 8 controls and n = 8 patients with CAA) in an ROI. In each box plot, the central line indicates the median and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. The whiskers extend to the most extreme data points not considered outliers; the outliers are plotted individually using the ‘+’ marker symbol. NS, not significant.
