Extended Data Fig. 6: Satiety sensitizes matings to CDN stimulation.
From: Behavioral devaluation by local resistance to dopamine
(A) Electrical silencing of the CDNs counteracts the satiety-induced increase in mating termination in response to a heat threat at 8 mins (n = 16-23). (B) Basal activity of the CDNs does not change with satiety state, as reported by normalizing GCaMP6s to tdTomato fluorescence (n = 10 each). (C) Satiety potentiates the response to a moderate heat threat similarly to moderate CDN activation (n = 22-26). (D) Satiety similarly potentiates the response to a strong heat threat and strong CDN activation (n = 25-34). (E) Satiety and D2R knockdown in the CDNs potentiate the response to direct stimulation of the CDNs similarly (n = 25-33).
