Fig. 1: Key cortical and subcortical regions involved in interoception and allostasis.
From: Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI
a, Using 3 Tesla fMRI resting state connectivity, we showed a unified system consisting of the default mode network (in red) and salience network (in blue), which overlapped in many key cortical visceromotor allostatic regions (in purple) that also serve as ‘rich club’ hubs (labeled in yellow), in addition to a portion of primary interoceptive cortex (dpIns; left)19. We reported the system’s connectivity to some subcortical regions known to have a role in control of the autonomic nervous system, the immune system and the endocrine system, such as the thalamus, hypothalamus, hippocampus, ventral striatum, PAG, PBN and NTS (for example, refs. 20,21,22,23,24,25,26; right)19. * denotes brainstem regions. Panel a is reproduced with permission from ref. 19. b, Expanded set of seed regions used in the present analysis. Hippo, hippocampus; hypothal, hypothalamus; IFG, inferior frontal gyrus; ITG, inferior temporal gyrus; PHG, parahippocampal gyrus; postCG, postcentral gyrus; STS, superior temporal sulcus; Thal, thalamus.
