Extended Data Fig. 5: Intrinsic connectivity of the hippocampus and its subregions within the allostatic-interoceptive system.
From: Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI
a, Bootstrapped connectivity maps obtained from resampling 80% of the sample (n = 72) 1000 times. b, Seed-to-seed connectivity strength between hippocampal seeds and all other seeds (two-tailed t-test, p < 0.05, uncorrected; white color indicates correlation = 1 and gray color indicates subthreshold correlations; n = 90). c, Contrasts obtained by paired-sample t-tests between subregional maps (two-tailed t-test, p < 0.05, uncorrected). Hippocampal head and body showed stronger connectivity to default mode nodes such as the MPFC, PCC, AG and lateral temporal cortex. Hippocampal body and tail showed stronger connectivity to salience nodes such as ACC, PCC, SMA, MFG and SMG. ACC: anterior cingulate cortex; aMCC: anterior midcingulate cortex; dAmy: dorsal amygdala; dmIns: dorsal mid insula; dpIns: dorsal posterior insula; DR: dorsal raphe; hypothal: hypothalamus; LC: locus coeruleus; LGN: lateral geniculate nucleus; lvAIns: lateral ventral anterior insula; mdThal: mediodorsal thalamus; MFG: middle frontal gyrus; mvAIns: medial ventral anterior insula; NAcc: nucleus accumbens; pACC: pregenual anterior cingulate cortex; PAG: periaqueductal gray; PBN: parabrachial nucleus; PCC: posterior cingulate cortex; SC: superior colliculus; sgACC: subgenual anterior cingulate cortex; SMA: supplementary motor area; SMG: supramarginal gyrus; SN: substantia nigra; VSM: medullary viscero-sensory-motor nuclei complex, including the nucleus tractus solitarius, dorsal motor nucleus of the vagus, nucleus ambiguus, and hypoglossal nucleus; VTA: ventral tegmental area.
