Extended Data Fig. 7: Intrinsic connectivity of the hypothalamus and its subregions within the allostatic-interoceptive system.
From: Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI
a, Bootstrapped connectivity maps obtained from resampling 80% of the sample (n = 72) 1000 times. b, Seed-to-seed connectivity strength between hypothalamic subregions and all other seeds (two-tailed t-test, p < 0.05, uncorrected; n = 90; white color indicates correlation = 1 and gray color indicates subthreshold correlations; n = 90). c, Contrasts obtained by paired-sample t-tests between subregional maps (two-tailed t-test, p < 0.05, uncorrected). The middle tuberal-posterior and superior communities showed more robust and extensive connectivity to midcingulate cortex and ventral mid insula than the anteroventral-tuberal and anterior communities, and the middle tuberal-posterior community further showed more extensive connectivity to posterior cingulate cortex and posterior insula. aMCC: anterior midcingulate cortex; AT HT: anteroventral-tuberal hypothalamus; dAmy: dorsal amygdala; dmIns: dorsal mid insula; dpIns: dorsal posterior insula; DR: dorsal raphe; hippo: hippocampus; HT: hypothalamus; LC: locus coeruleus; LGN: lateral geniculate nucleus; lvAIns: lateral ventral anterior insula; mdThal: mediodorsal thalamus; MTP HT: middle tuberal-posterior hypothalamus; mvAIns: medial ventral anterior insula; NAcc: nucleus accumbens; pACC: pregenual anterior cingulate cortex; PAG: periaqueductal gray; PBN: parabrachial nucleus; PCC: posterior cingulate cortex; SC: superior colliculus; sgACC: subgenual anterior cingulate cortex; SN: substantia nigra; VSM: medullary viscero-sensory-motor nuclei complex, including the nucleus tractus solitarius, dorsal motor nucleus of the vagus, nucleus ambiguus, and hypoglossal nucleus; VTA: ventral tegmental area.
