Extended Data Fig. 4: Correlation between age-specific and brain-region–specific m6A methylation and gene expression. | Nature Neuroscience

Extended Data Fig. 4: Correlation between age-specific and brain-region–specific m6A methylation and gene expression.

From: Multi-region m6A epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci

Extended Data Fig. 4

(A) Comparison of BA9 age-specific m6A methylation log2 FC values with other brain regions (B) Comparison of BA9 brain-region–specific m6A methylation log2 FC values with other brain regions (C) Heatmap showing the gene expression values of genes marked with brain-region–specific m6A methylation (rows), with red indicating high expression and blue indicating low expression. Majority of brain-region–specific m6A marked genes have consistent gene expression across all brain regions (indicated by blue bar). Some brain-region–specific have brain-region–specific expression (indicated by orange bar). (D) Scatterplots showing the correlation between normalized m6A levels and normalized gene expression values for each brain region.

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