Extended Data Fig. 9: Caveolae enrichment and cell junction reduction induced by endothelial FOXF2 deficiency in the mouse. | Nature Neuroscience

Extended Data Fig. 9: Caveolae enrichment and cell junction reduction induced by endothelial FOXF2 deficiency in the mouse.

From: A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions

Extended Data Fig. 9: Caveolae enrichment and cell junction reduction induced by endothelial FOXF2 deficiency in the mouse.The alternative text for this image may have been generated using AI.

a. Representative immunohistochemistry of mouse brain slices stained for CAV1 (right) and TJP1 (left) with quantification of mean intensity (n = 19–20 replicates/sample; normalized to Ctrl; two-tailed T-test, P =0.038, P<0.0001. Scale bar 25 µm. b. Immunogold localization of CAV1 in KO endothelium using electron microscopy (n = 1 replicate/sample). Scale bar 0.5 µm. Bar graphs show mean ± SD.

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