Extended Data Fig. 1: Human microglia in the brain of AppNL-G-F mice. | Nature Neuroscience

Extended Data Fig. 1: Human microglia in the brain of AppNL-G-F mice.

From: The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia

Extended Data Fig. 1: Human microglia in the brain of AppNL-G-F mice.The alternative text for this image may have been generated using AI.

a, Representative sagittal brain section showing the distribution of human engrafted microglia (labeled with human P2RY12, in magenta, and IBA1, in cyan) in AppNL-G-F Csf1rΔFIRE/ΔFIRE mice at 4 months of age (X-34+ plaques in yellow). Because these mice genetically lack mouse microglia, engraftment efficiency reaches 100%. Scale bar = 1 mm. b, Higher magnification confocal image of representative X-34 plaques (in yellow) surrounded by human microglia expressing IBA1 (cyan) and P2RY12 (magenta) at 4 months of age. Scale bar = 50 µm. c, Representative high-magnification confocal z-stacks of X-34 plaques (green) surrounded by human microglia expressing CD9 (cyan), HLA (yellow) and CD68 (magenta) at 6 months of age. Scale bar = 50 µm. Images shown are representative; sagittal sections at 4 months were obtained from 2 mice (a,b), high-magnification confocal z-stacks at 6 months from 4 mice (c).

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