Extended Data Fig. 7: Assessment of infarct size and BBB leakage 1 day after stroke in Foxf2iECKO and Ctrl mice treated with either vehicle or AKB-9778 prior to fMCAO. | Nature Neuroscience

Extended Data Fig. 7: Assessment of infarct size and BBB leakage 1 day after stroke in Foxf2iECKO and Ctrl mice treated with either vehicle or AKB-9778 prior to fMCAO.

From: The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling

Extended Data Fig. 7: Assessment of infarct size and BBB leakage 1 day after stroke in Foxf2iECKO and Ctrl mice treated with either vehicle or AKB-9778 prior to fMCAO.

a, Experimental outline. Vehicle or AKB-9778-treated Foxf2iECKO and Ctrl mice underwent middle cerebral artery occlusion (MCAO) followed by Evans blue injection and micro-MRI prior to brain dissection and confocal imaging. Infarct size was determined 1 day after experimental stroke induction (1 dps). b, Serial coronal MRI scans of about 8 consecutive regions. Panels a and b were created with BioRender.com. c, Exemplary magnetic resonance scans from Ctrl-Veh, Foxf2iECKO-Veh, and Foxf2iECKO-AKB mice. Shown are consecutive slices (T2-weighted sequence), scale bar = 5 mm.

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