Extended Data Fig. 9: Cytokine-induced genes are consistent across macrophage clusters.
From: In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation
a, Proportion of downregulated genes in the KO vs the control that are unique to the cluster or shared between more than one cluster. Numbers at the top of each column indicate the total number of downregulated DEGs per cluster. Downregulated DEGs per KO are defined as genes significantly downregulated (adjusted p-value < 0.05 and log2(Fold Change) < 2 x standard deviation of the log2(Fold Change) distribution of the comparison as analyzed by Seurat FindMarkers) for the same cluster in either the Hoxb8FL-derived KO cells compared to the Hoxb8FL control or the chimeric KO cells compared to the chimeric control. b, Downregulated gene overlap across KOs. See Methods for definition of downregulated genes in the KO. Numbers below the KO name indicate total genes downregulated in that KO, numbers inside of the circles indicate genes uniquely downregulated in that KO, and numbers on the edges indicate genes regulated by the two connected KOs.
