Extended Data Fig. 10: Characterization of neuroinflammatory cytokine signatures and myeloid cells from human CSF and tissue samples.
From: In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation
a, Neuroinflammatory cytokine signature expression across different cytokine injected samples based on Cui et al. (ref. 31). Dots represent the mean, lines the standard deviation b, Expression of myeloid markers in CSF monocyte/macrophages c, Distribution of the gene counts of all detected genes across CSF datasets. d, Characterization of human microglial clusters. e, Distribution of the gene counts of all detected genes across Macnair et al. (ref. 35) lesion types. f, Distribution of the gene counts of all detected genes across Mathys et al. (ref. 36) pathology. g, Distribution of the gene counts of all detected genes across Macnair et al. (ref. 35) microglial clusters. b, e-g, Dots represent the mean. Boxplot line shows median, box Q1 and Q3, and whiskers the interquantile range x 1.5.
