Fig. 7: Neuroinflammatory cytokine signatures connect myeloid cell regulation across MS models.
From: In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation
a, Scheme illustrating how we derived neuroinflammatory cytokine signatures. b, Expression of the averaged neuroinflammatory cytokine signatures in the WT EAE UMAP. c, Scheme of the CSF extraction procedure from the cisterna magna (left) and UMAP of the immune cells present in CSF of EAE animals at the peak of disease (right). d,e, Expression of the averaged neuroinflammatory cytokine signatures in the CSF EAE UMAP. f, Scheme of the induction of the cortical MS (cMS) disease model (left) and UMAP of the immune cells present in the cortex of cMS animals at the peak of inflammation (right). i.c., intracortically. g,h, Expression of the averaged neuroinflammatory cytokine signatures in the cMS UMAP. DEGs, differentially expressed genes.
