Extended Data Fig. 10: Additional computational modeling of synapse dynamics.
From: Extracellular matrix proteolysis maintains synapse plasticity during brain development
a) Fitting of synapse lifetime data in Fig. 3q from mmp14b−/−;Chat-PSD95FingR fish, based on the two-state model in Fig. 7a. Density of synapses for each category of lifetime are shown from raw data and as predicted by the two-state model. The numbers in parentheses indicate the time point of first and last observation of synapses during the time course over 72 h. b) Schematic of a “one state” model of synapse dynamics.c) Attempted fit of experimental data from control fish in Fig. 1m to a “one state” model shows poor alignment. Compare also Supplemental File 1 for a detailed comparison of the model fits. The numbers in parentheses indicate the time point of first and last observation of synapses during a time course over 72 h.
