Fig. 3: HSV-1 capsids bind to intraneuronal tau and stimulate aggregation. | Nature Neuroscience

Fig. 3: HSV-1 capsids bind to intraneuronal tau and stimulate aggregation.

From: Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons

Fig. 3: HSV-1 capsids bind to intraneuronal tau and stimulate aggregation.

Co-incubated isolated HSV-1 capsids and 2N4R GSK-3β p-tau were analyzed by TEM. a,b, Co-incubated HSV-1 capsid (arrows) and 2N4R GSK-3β p-tau displayed amorphous tau aggregates (triangles) and fibrillar tau structures (*) emanating from viral capsid surfaces. c, 3D ReNcell VM cultures infected with HSV-1 were sliced and probed with anti-p-tau-Au nanoparticles. d, Inside the cell nucleus, HSV-1 capsids were identified with anti-p-tau-Au binding on their surface (arrows). Micrographs are representative of data from multiple discrete imaging fields (n = 3).

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