Fig. 7: p-tau and HSV-1 co-localize inside microglia. | Nature Neuroscience

Fig. 7: p-tau and HSV-1 co-localize inside microglia.

From: Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons

Fig. 7: p-tau and HSV-1 co-localize inside microglia.

Mature microglia were added to 3D ReNcell VM cultures prior to infection with HSV-1 to analyze the interaction among p-tau, HSV-1 and microglia. Uninfected and infected microglia−ReNcell VM cultures were immunoprobed with anti-p-tau (PHF1) and anti-IBA1 labeled with fluorescent secondary antibodies and analyzed for microglia (405), neurons (GFP), HSV-1 (RFP) and p-tau (647) fluorescence by confocal microscopy. Co-localization of HSV-1 (red) and p-tau (purple) inside of microglia (blue) was observed (arrows). Panels are representative of multiple image fields (n = 5).

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