Precision neuroimaging of repeatedly scanned individuals receiving deep brain stimulation (DBS), conducted longitudinally with long scanning durations, revealed separate globus pallidus and motor cortex (M1) circuits with distinct frequency- and time-dependent responses. DBS also evoked divergent effects in M1 functional connectivity, normalizing within the somato-cognitive action network but denormalizing in effector motor networks.
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References
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This is a summary of: Ren, J. et al. Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans. Nat. Neurosci. https://doi.org/10.1038/s41593-026-02228-w (2026).
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Mapping deep brain stimulation-modulated circuits via precision neuroimaging. Nat Neurosci (2026). https://doi.org/10.1038/s41593-026-02229-9
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DOI: https://doi.org/10.1038/s41593-026-02229-9
