Fig. 2: Mapping neuropeptide receptor topographies across the human brain.
From: Organization of neuropeptide systems in the human brain
Neuropeptide receptor topographies stratified according to anatomical and functional landmarks. a, Mean expression of individual neuropeptide receptors in the cortex, hypothalamus and subcortex. Cortical receptor expression was stratified according to canonical intrinsic functional networks (visual, somatomotor, dorsal attention, ventral attention, frontoparietal, default mode and limbic)17. Subcortical receptor expression was stratified according to a functional atlas (amygdala, caudate nucleus, globus pallidus, hippocampus, nucleus accumbens, putamen and thalamus)18. Hypothalamic expression was aggregated from eight nuclei localized in the hypothalamus delineation of the CIT168 atlas19. b, Box plots of neuropeptide receptor expression within the cortex (n = 400), subcortex (n = 54) and hypothalamus (n = 1), with medians plotted on the right. The bounds of the box plots represent the first (25%) and third (75%) quartiles; the center line represents the median; the whiskers represent the minima and maxima. Receptors are colored according to family membership and vertically sorted using hierarchical clustering.
