Pain in rheumatoid arthritis often persists independently of joint inflammation. In this issue, Su et al. demonstrate that sustained non-canonical type 1 interferon signaling within peripheral sensory neurons maintains hypersensitivity long after inflammation subsides, revealing a potential therapeutic avenue for chronic arthritic pain.
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Staurengo-Ferrari, L., Wong, C. & Chiu, I.M. Neuroimmune interferon signals sustain arthritis pain. Nat Neurosci (2026). https://doi.org/10.1038/s41593-026-02251-x
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DOI: https://doi.org/10.1038/s41593-026-02251-x
