Supplementary Figure 1: The SMARCA4 ATP cleft and DNA groove are frequently mutated in cancer.
From: Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers
(a) Surface rendering of the SMARCA4 homology model viewed from the DNA-binding surface. Details of homology model are described in the Methods section. Surface residues are colored based on mutation frequency of deleterious missense mutations at the time of analysis in cBioPortal, for residue positions 758–1335. DNA is shown in yellow. (b) Rotation of the view in (a) 90° around the x-axis to show the ATP-binding cleft. ATP is shown in blue. (c) Rotation of the view in (a) 180° around the y-axis. (d) Rotation of the view in (c) –90° around the x-axis reveals few other surface mutation hotspots.
