Supplementary Figure 2: Visualization and analysis page

The biomolecular complex network panel, sequence panel, 3D structure panel and contacts panel are shown for the β2 adrenergic receptor-G protein complex structure (PDB ID: 3SN6). The sequence panel shows the secondary structure elements (SSEs) and the amino acid sequence. In the sequence panel, some positions are highlighted with a line on the top, using bold typeface or a red color. A line on top of a residue denotes availability of disease mutation data via Uniprot, which can be accessed by moving the mouse over the residue. Bold letters denote residues that were previously hovered over. Red colored letters denote residues currently selected. Helices are represented as rectangles and sheets are represented by arrows. The top line shows the entire SSEs of the chain and the line below shows the zoomed in version with the loops as a thin black line. The size of the rectangles and arrows are proportional to the length of the SSEs. The contacts panel shows the secondary structures view in which the chord plot can be seen on the top left corner with the selected secondary structures (Helix 38 in blue and Helix 40 in orange). In the middle, the residue contact matrix is shown with all the contacting residues of the selected SSEs. The residues belonging to each SSE are highlighted in their respective colors. The number of atomic contacts is shown within the matrix. On the right is the 3D structure panel, which shows the 3D view of the receptor (grey cartoon view).