Supplementary Figure 5: Sequence alignment of TRPV channels.
From: Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms
Sequences of Xenopus tropicalis TRPV4 (xTRPV4, Gene ID: 100496204), Homo sapiens TRPV4 (hTRPV4, Gene ID: 59341), Homo sapiens TRPV1 (hTRPV1, Gene ID: 7442), Homo sapiens TRPV2 (hTRPV2, Gene ID: 51393), Homo sapiens TRPV3 (hTRPV3, Gene ID: 162514), Homo sapiens TRPV5 (hTRPV5, Gene ID: 56302), and Homo sapiens TRPV6 (hTRPV6, Gene ID: 55503) were aligned. Secondary structure elements of xTRPV4 are shown above the sequence, and dashed lines indicate unresolved regions in the cryo-EM structure. Disease mutations discussed in the main text are highlighted in the same colors as in Fig. 6a.
