Supplementary Figure 1: Relative molecular motions between S4 and S5 upon voltage activation. | Nature Structural & Molecular Biology

Supplementary Figure 1: Relative molecular motions between S4 and S5 upon voltage activation.

From: Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel

Supplementary Figure 1: Relative molecular motions between S4 and S5 upon voltage activation.

(a and b) Average distance differences between the S4 helix and the S5 helix on the adjacent subunit. The differences represent the average distance of c-α atoms in the activated minus the average distance of c-α atoms in the resting state. (c and d) A cartoon representation showing two different types of motions that can occur during voltage-sensing displacement of S4. Panel C shows the downward deflection of S4 and the effect on residue distances between S4 and S5 whereas panel D show a reorientation of the angle between the long axis of S4 and S5 helix.

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