Supplementary Figure 2: Conformations of TIRR 53BP1-binding loop and corresponding loop region in NUDT16. | Nature Structural & Molecular Biology

Supplementary Figure 2: Conformations of TIRR 53BP1-binding loop and corresponding loop region in NUDT16.

From: Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

Supplementary Figure 2: Conformations of TIRR 53BP1-binding loop and corresponding loop region in NUDT16.

Left: Amino acid sequence alignment of TIRR 53BP1-binding loop with corresponding region of NUDT16. Right: Structural overlay of the loop regions in TIRR (blue) and NUDT16 (gray). Highlighted are Pro104 and Arg105 in NUDT16 and key 53BP1-interacting residues Pro105 and Arg107 in TIRR. 53BP1 residues interacting with TIRR Pro105 and Arg107 are also shown.

Back to article page